Kevin Campbell

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Select Publications

Name: Kevin Campbell

Position Title: Professor

Office Phone Number: (204) 474-6397

Research and Teaching Interests

My research utilizes molecular biology techniques in conjunction with physiological and metabolic studies to study the hemoglobin oxygen-affinity, energetics and evolutionary physiology of shrews and moles (and other semi-aquatic mammals), with a focus on the specializations these insectivores have evolved to cope with hypoxia/hypercapnia and temperature. Our lab is also actively spearheading several projects that are focused on elucidating the functional/structural properties and physiochemical evolution of authentic gene products resurrected from DNA sequences of extinct mammalian species (e.g. woolly mammoth, woolly rhinoceros and Steller’s sea cow). More information can be found at my personal website .

Research Interests

Paleophysiology of extinct Pleistocene mammals, Physiology, Evolutionary, molecular and environmental physiology of mammals, Evolutionary physiology of fossorial and semi-aquatic insectivores

Links

http://home.cc.umanitoba.ca/~campbelk/

Gaudry, MJ and KL Campbell (2017). Evolution of UCP1 transcriptional regulatory elements across the mammalian phylogeny. Frontiers in Physiology 8, 670.
Gaudry, M.J., M. Jastroch, J.R. Treberg, M. Hofreiter, J.L.A. Paijmans, J. Starrett, N. Wales, A.V. Signore, M.S. Springer, and K.L. Campbell (2017). Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades.Science Advances 3 (7), E1602878.
He, K., A. Shinohara, K.M. Helgen, M.S. Springer, J. Xue-Long and K.L. Campbell (2017). Talpid mole phylogeny unites shrew moles and illuminates overlooked cryptic species diversity. Molecular Biology and Evolution 34 (1), 78-87.
Campbell, K.L. and M. Hofreiter (2015). Resurrecting phenotypes from ancient DNA sequences: promises and perspectives. Canadian Journal of Zoology 93 (9), 701-710.
Springer, M.S., A.V. Signore, J.L.A. Paijmans, D.P. Domning, J. Velez-Juarbe, C. Bauer, K. He, L. Crerar, P.F. Campos, W.J. Murphy, R.M. Meredith, J. Gatesy, E. Willerslev, R.D.E. MacPhee, M. Hofreiter and K.L. Campbell. (2015). Interordinal gene capture, the phylogenetic position of Steller’s sea cow based on molecular and morphological data, and the macroevolutionary history of Sirenia. Molecular Phylogenetics and Evolution 91 (10), 178-193.
Gaudry, M.J., J.F. Storz, G.T. Butts, K.L. Campbell and F.G. Hoffmann (2014).Repeated evolution of chimeric fusion genes in the β-globin gene family of laurasiatherian mammals. Genome Biology and Evolution 6 (5), 1219-1233.
Hare, J.F., K.L. Campbell and R.W. Senkiw (2014). Catch the wave: Prairie dogs assess neighbours’ awareness using contagious displays. Proceedings of the Royal Society B: Biological Sciences 281 (1777), 20132153.
He, K., A. Shinohara, J. Xue-Long and K.L. Campbell (2014). Multilocus phylogeny of Talpine moles (Talpini, Talpidae, Eulipotyphla) and its implications for systematics.Molecular Phylogenetics and Evolution 70 (1), 513-521.
Schwarze, K., K.L. Campbell, T. Hankeln, J.F. Storz, F.G. Hoffmann and T. Burmester (2014). The globin gene repertoire of the lamprey: Convergent evolution of hemoglobin and myoglobin in jawed and jawless vertebrates. Molecular Biology and Evolution, doi: 10.1093/molbev/msu216 .
Weber, R.E., A. Fago and K.L. Campbell (2014). Enthalpic partitioning of the reduced temperature sensitivity of O2 binding in bovine hemoglobin. Comparative Biochemistry and Physiology – Part A 176 (10), 20-25.
Mirceta, S., A.V. Signore, J.M. Burns, A.R. Cossins, K.L. Campbell and M. Berenbrink (2013). Evolution of mammalian diving capacity traced by myoglobin net charge.Science 340 (6138), 1234192.
Campbell, K.L. and M. Hofreiter (2012). New life for ancient DNA. Scientific American 307 (2), 46-51.
Campbell, K.L., A.V. Signore, M. Harada and R.E. Weber (2012). Molecular and physicochemical characterization of hemoglobin from the high-altitude Taiwanese brown-toothed shrew (Episoriculus fumidus). Journal of Comparative Physiology B 182(6), 821-829.
Noguchi, H., K. L. Campbell, C. Ho., S. Unzai, S.-Y. Park and J.R.H. Tame (2012). The structures of hemoglobin from the woolly mammoth in liganded and unliganded states.Acta Crystallographica Section D: Biological Crystallography 68 (11), 1441-1449.
Sato, J.J., M. Wolsan, F.J. Prevosti, G. D’Elia, C. Begg, K. Begg, T. Hosoda, K.L. Campbell and H. Suzuki (2012). Evolutionary and biogeographical history of weasel-like carnivorans (Musteloidea). Molecular Phylogenetics and Evolution 63 (3), 745-757.
Signore, A.V., J. Stetefeld, R.E. Weber and K.L. Campbell. (2012). Origin and mechanism of thermal insensitivity in mole hemoglobins: a test of the ‘additional’ chloride binding site hypothesis. Journal of Experimental Biology 215 (3), 518-525.
Weber, R.E. and K.L. Campbell (2011). Temperature dependence of haemoglobin-oxygen affinity in heterothermic vertebrates: mechanisms and biological significance.Acta Physiologica 202 (3), 549-562.
Yuan, Y., T-J. Shen, P. Gupta, N.T. Ho, V. Simplaceanu, T.C.S. Tam, M. Hofreiter, A. Cooper, K.L. Campbell and C. Ho (2011). A biochemical-biophysical study of hemoglobins from woolly mammoth, Asian elephant, and humans. Biochemistry 50(34), 7350-7360.
Campbell, K.L., J.E.E. Roberts, L.N. Watson, J. Stetefeld, A.M. Sloan, A.V. Signore, J.W. Howatt, J.R.H. Tame, N. Rohland, T-J. Shen, J.J. Austin, M. Hofreiter, C. Ho, R.E. Weber and A. Cooper (2010). Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance. Nature Genetics 42 (6), 536-540.
Campbell, K.L., J.F. Storz, A.V. Signore, H. Moriyama, K.C. Catania, A. Payson, J. Bonaventura, J. Stetefeld and R.E. Weber (2010). Molecular basis of a novel adaptation to hypoxic-hypercapnia in a strictly fossorial mole. BMC Evolutionary Biology 10, 214.