Research and Teaching Interests
- Investigation of the nature and origin of conformational effects.
- Synthesis and conformational analysis of oligosaccharide antigenic determinants.
- Molecular recognition in antibody-antigen interaction.
- Development of immunodiagnostic reagents and vaccines employing carbohydrate antigens.
- Design of glycosylation inhibitors for control of microbial infections and chronic mammalian conditions, e.g. cancer, type-2 diabetes.
- Interaction between transition-state- and non-hydrolyzable substrate analogues and carbohydrases
- Synthesis, conformational analysis, and reactions of organosulfur and organoselenium compounds.
- Discovery of peptide mimics of oligosaccharide epitopes for immunodiagnostics, vaccines, and therapeutics.
- Transferred-NOE/STD NMR spectroscopy.
- Bound conformations of ligands by combined NMR/Molecular dynamics protocols.
- Structure and dynamics of oligosaccharides.
- Synthetic methods in carbohydrate chemistry.
- Nucleoside and nucleotide analogues as antiviral agents.
- Nucleotide analogues as gene-silencing agents.
- Control of glycoprotein trafficking in cells.
- Development of analytical methods for glycan profiling.
- Modulation of convertase activity in cells.
- Modulation of lipid-linked oligosaccharide biosynthesis.
- Modulation of UDP-Galp mutase activity in tuberculosis.
- Modulation of intestinal glucosidase activities for control of obesity, type-2 diabetes, and other metabolic disorders.
Most Significant Contributions to Research and/or to Practical Applications:
- This review article (Johnson, M.A.; Pinto, B.M. Topics in Current Chem., 2008, 273: 55–116) summarizes our unprecedented work on the nature of mimicry of carbohydrates by peptides, and provides a hypothesis for functional vs. structural mimicry. The discovery has implications for the design of more economical, higher affinity vaccines, and is being pursued by e.g. l’Institut Pasteur, Paris. We have “gone the distance” with this program, from the molecule to the system, and have published in the immunology literature (Borrelli, S., et al. J. Immunol., 2006, 2: 73-83; Clin. Vaccine Immunol., 2008, 15: 1106-1117); this complements our carbohydrate-based vaccine program, also recognized by the immunology community (Infect. Immun., 2005, 73: 6383-6389).
- Contribution #2 ( Natl. Acad. Sci., 2003, 100: 15023-15028; Biochemistry, 2002, 41: 13575- 13586) describes crystallographic evidence of a peptide-mimic antibody complex and its comparison to a complex of the same antibody with its native oligosaccharide ligand. This is a significant milestone since it was the first time that a direct comparison of a carbohydrate and its peptide mimic in complex with a common protein receptor was possible. The results provide support for our hypothesis (Contribution #1) of the nature of mimicry, and has now allowed us to test theories of mimicry (J. Biol. Chem., 2003, 278: 24740-24752) and to design higher-affinity, glycopeptide ligands (Carbohydr. Res., 2009, 344: 1412-1427) that might find use as vaccines.
- A state-of-the-art STD-NMR/molecular dynamics protocol for probing protein-ligand interactions (ChemBioChem., 2009, 10: 2052-2059; Med. Chem., 2010, 18: 5123-5128; Chem. Eur. J., 2011, 17: 11438-11445; Chem. Eur. J., 2011, 17: 11446-11455; ChemBioChem. 2016, 17: 2264-2273.) has been developed. This protocol is very powerful in that computed structures are validated by experimental information—the correlation is based on a calculation of relaxation and exchange effects that are then compared to experimentally-derived STD effects. We are one of the few groups doing quantitative work in this field. This protocol yielded the only structural model (at the time) for UDP-galactopyranose mutase in complex with substrates and inhibitors that was used for future inhibitor design (Biochemistry, 2005, 44: 14080-14089; J. Am. Chem. Soc., 2008, 130: 3157-3168; Proteins: Structure, Function, and Bioinformatics., 2009, 74: 972-979).
- The synthesis of sulfonium ions as mimics of alkaloid glycosidase inhibitors (protonated in the active site) has yielded valuable insights into the nature of this mimicry ( Org. Chem., 2006, 71: 2935-2943; J. Org. Chem., 2006, 71: 1262-1264; Carbohydr. Res., 2006, 341: 1685-1691; Carbohydr. Res., 2007, 342: 901-912; Proteins: Structure, Function, and Bioinformatics, 2008, 71: 1484-1496). The program has led also to the structure elucidation and synthesis of active ingredients (and analogues thereof) of an herbal treatment for diabetes that has been used in Indian traditional medicine. These compounds are glucosidase inhibitors and have considerable potential for the treatment of Type-2 diabetes by inhibiting the action of intestinal glucosidases, or for development of diagnostic tests (Clin. Chem., 2004, 50: 1785-1796). The active sites of key intestinal enzymes have been mapped (FEBS Journal., 2006, 273: 2673-2683; Carbohydr. Res., 2007, 342: 1551-–1582; J. Org. Chem., 2007, 72: 806-812; J. Org. Chem., 2008, 73: 6172-6181; Coll. Czech Republic Commun., 2009, 74: 1117-1136; Biochemistry, 2010, 49: 443–451; J. Biol. Chem., 2010, 285: 17763-17770; Natural Product Reports, 2010, 27: 481-488; Bioorg. Med. Chem., 2010, 18: 2829–283; Bioorg. Med. Chem. Lett., 2011, 21: 6491; Org. Lett., 2010, 12: 1088-1091; Org. Lett., 2010, 12: 1632-1635; J. Chem. Soc., Chem. Commun. 2011, 47: 9134-9136; Chem. Eur. J., 2011, 17: 14817-14825; J. Biol. Chem., 2012, 287: 31929-31938. The work has been reviewed recently in Acc. Chem. Res. 2014, 47 (1): 211–225). A landmark achievement was the structure elucidation of the natural product kotalanol (J. Am. Chem. Soc., 2009, 131: 5621-5626). Most recently, we have examined taste cell-expressed glucosidase activity (Proc. Natl. Acad. Sci., 2016, 113: 6035-6040).
- We were the first to develop the selenium Pummerer reaction ( Am. Chem. Soc., 2006, 128: 227-239), and have applied this reaction and that of its sulfur congener, in collaboration with Masad Damha, to the synthesis of novel oligonucleotides containing Se and S in the ribose ring, with si-RNA activity (J. Am. Chem. Soc., 2008, 130: 8578-8579; Nucleic. Acids Res., 2007, 35: 1441-1451).
- We have explored the modification of oligosaccharide content on glycoproteins as control elements for intra-cellular trafficking during N-glycoprotein biosynthesis, and have achieved spectacular results using small molecules as triggers (Glycobiology, 2011, 21: 1290-1300). Control of cholesterol biosynthesis and β-endorphin has been achieved. We have shown that these changes are a result of blocking the biosynthesis of dolichol-linked oligosaccharides and mimic Class I congenital disorders of glycosylation (, 2011, 13: 392-401). With David Vocadlo, we have also extended this approach to modify cell-surface expression of oligosaccharide markers that mediate inflammation and cancer propagation (J. Biol. Chem., 2012, 287: 40021-40030)
PUBLICATIONS (2011-Present)
Journal Articles
181. Albohy, A.*, S. Mohan*, B.M. Pinto, C.W. Cairo (2011). The Limited Potency of Oseltamivir Analogs Against Human Neuraminidases Provides a Strategy for Improving the Selectivity of Influenza Viral Neuraminidase Inhibitors. Bioorg. Med. Chem. 19: 2817-2822. (NSERC Disc)
- Szczepina, M.G.*, D.W. Bleile*, J. Müllegger*, A.R. Lewis, B. M. Pinto (2011). WaterLOGSY NMR Experiments in Conjunction with Molecular Dynamics Simulations Detect Immobilized Water Molecules that Bridge Peptide Mimic MDWNMHAA to Anti-carbohydrate Antibody SYA/J6. Chem. Eur. J. 17: 11438-11445. (NSERC Disc). Selected for frontispiece.
- Zandberg, W.F.*, S. Benjannet, J. Hamelin, B. M. Pinto, N.G. Seidah (2011). N-glycosylation Controls Trafficking, Zymogen Activation, and Substrate Processing of Proprotein Convertases PC1/3 and SKI-1. Glycobiology. 21: 1290-1300. (NSERC Disc)
- Niikura, M., N. Bance*, S. Mohan*, B.M. Pinto (2011). Replication Inhibition Activity of Carbocycles Related to Oseltamivir on Influenza A Virus in vitro. Antiviral Res. 90: 160-163. (NSERC Disc)
- Jones, K.*, L. Sim*, S. Mohan*, J. Kumarasamy, H. Liu*, S. Avery*, H. H. Naim, R. Quezada-Calvillo, B. L. Nichols, B. M. Pinto, D. R. Rose (2011). Mapping the Intestinal a-Glucogenic Enzyme Specificities of Starch-digesting Maltase-glucoamylase and Sucrase-isomaltase. Bioorg. Med. Chem. 19: 3929-3934. (CIHR)
- Fernández-Herrera, M.A.*, H. López-Muñoz, J. M. V. Hernández-Vázquez, M. López-Dávila, S. Mohan*, M. L. Escobar-Sánchez, L. Sánchez-Sánchez, B. M. Pinto, J. Sandoval-Ramírez (2011). Synthesis and Biological Evaluation of the Glycoside (25R)-3,16-Diacetoxy-22-oxocholest-5-en-26-yl-b-D-glucopyranoside: A Selective Anticancer Agent in Cervicouterine Cell Lines. Eur. J. Med. Chem. 46: 3877-3886. (NSERC Disc)
- Szczepina, M.G.*, D.W. Bleile*, B.M. Pinto (2011). Investigation of the Binding of a Carbohydrate-mimetic Peptide to its Complementary Anti-carbohydrate Antibody by STD-NMR Spectroscopy and Molecular Dynamics Simulations. Chem. Eur. J. 17: 11446-11455. (NSERC Disc)
- Eskandari, R.*, K. Jones*, R. R. Kongara*, K. Jayakanthan*, M. Chaudet*, D. R. Rose, B. M. Pinto (2011). Probing the Intestinal -Glucosidase Enzyme Specificities of Starch-digesting Maltase-glucoamylase and Sucrase-isomaltase: Synthesis of 3′- and 5′- Maltose-extended De-O-sulfonated Ponkoranol. Chem. Eur. J. 17: 14817–14825. (CIHR)
- Eskandari, R.*, K. Jones*, D. R. Rose, B. M. Pinto (2011). Probing the Intestinal -Glucosidase Enzyme Specificities of Starch-digesting Maltase-glucoamylase and Sucrase-isomaltase: The Effect of Heteroatom Substitution of Sulfur for Selenium on Enzyme Specificity. J. Chem. Soc., Chem. Commun. 47: 9134- 9136. (CIHR)
- Zandberg, W.F.*, N. Gao*, J. Kumarasamy, M. A. Lehrman, N. G. Seidah, B. M. Pinto (2011). 5-Thiomannosides Block the Biosynthesis of Dolichol-linked Oligosaccharides and Mimic Class I Congenital Disorders of Glycosylation. ChemBioChem. 13: 392-401. (NSERC Disc)
- Eskandari, R.*, K. Jones*, R. Rose, B. M. Pinto (2011). Selectivity of 3′-O-Methylponkoranol for
Inhibition of N– and C-terminal Maltase Glucoamylase and Sucrase Isomaltase, Therapeutic Targets for Digestive Disorders and Their Sequelae. Bioorg. Med. Chem. Lett. 21: 6491-6494. (CIHR)
- Shi, Y.*, B.M. Pinto (2012). Molecular dynamics simulations of carbohydrate-mimetic haptens in complex with a complementary anti-carbohydrate antibody. Res. 358: 89-95. (NSERC DISC)
- Fernández-Herrera, M. A.*, H. López-Muñoz, J. M. V. Hernández-Vázquez, L. Sánchez-Sánchez, L. Escobar-Sánchez, B. M. Pinto, J. Sandoval-Ramírez (2012). Synthesis and selective anticancer activity of steroidal glycoconjugates. Eur. J. Med. Chem. 54: 721-727. (NSERC Disc)
- Mohan, S.*, McAtamney*, K. Jayakanthan*, R. Eskandari*, M. von Itzstein, B M. Pinto (2012). Antiviral Activities of Sulfonium-Ion Glucosidase Inhibitors and 5-Thiomannosylamine-Disaccharide Derivatives Against Dengue Virus. Int. J. Antimicrob. Agents. 40: 273-276. (NSERC Disc)
- Lee, B.-H.*, R. Eskandari*, K. Jones*, R.K. Reddy*, R. Quezada-Calvillo, B. Nichols, D.R. Rose, B. Hamaker, B.M. Pinto (2012). Modulation of Starch Digestion for Slow Glucose Release Through “Toggling” of Activities of Mucosal α-Glucosidases. Biol. Chem. 287: 31929-31938. (CIHR)
- Jones, K.*, R. Eskandari*, H.H. Naim, B.M. Pinto, D.R. Rose, (2012). Investigations of the Structures and Properties of the Human Intestinal Enzymes MGAM and SI. Pediatr. Gastroenterol. Nutr. 55: S20-S24. (CIHR)
- Greenway, K.L.*, A.G. Bischoff*, B.M. Pinto (2012). Hyperconjugation as Probed Experimentally with the Conformational Deuterium Isotope Effect. Org. Chem. 77: 9221−9226. (NSERC Disc)
- Zandberg, W.*, J. Kumarasamy, B.M. Pinto, D. Vocadlo (2012). Metabolic Inhibition of Sialyl-LewisX Biosynthesis by 5-Thiofucose Remodels the Cell Surface and Impairs Selectin-Mediated Cell Adhesion. Biol. Chem. 287: 40021-40030. (NSERC Disc)
- Dahabieh, M.S.*, D. Samantha*, J.-C. Brodovitch, C. Frech*, M.A. O’Neill, B.M. Pinto (2012). Sequence Dependent Structural Dynamics of Primate Adenosine-to-Inosine Editing Substrates. ChemBioChem 13: 2714–2721. (NSERC Disc)
- Greenway, K.L.*, E.B. LeGresley*, B.M. Pinto (2013). The Influence of 150-Cavity Binders on the Dynamics of Influenza A Neuraminidases as Revealed by Molecular Dynamics Simulations and Combined Clustering. PLoS ONE. 8(3): e59873. doi:10.1371/journal.pone.0059873 (NSERC Disc)
- Gu, G.*, P.J.P. Adabala*, M.G. Szczepina*, S. Borrelli*, B.M. Pinto (2013). Synthesis and Immunological Characterization of Modified Hyaluronic Acid Hexasaccharide-conjugates. Org. Chem. 78: 8004−8019. dx.doi.org/10.1021/jo4012442 (NSERC Disc).
- Kerry, P., S. Mohan*, R.J. Russell, N. Bance*, M. Niikura, B.M. Pinto (2013). Structural basis for a class of nanomolar influenza A neuraminidase inhibitors. Scientific Reports (Nature Publishing Group) 3: 2871− doi: 10.1038/srep02871. (NSERC Disc).
- Mohan, S.*, R. Eskandari*, B.M. Pinto (2014). Naturally Occurring Sulfonium-ion Glucosidase Inhibitors and their Derivatives: A Promising Class of Antidiabetic Agents. Chem. Res. 47: 211-225. doi: 10.1021/ar400132g. (NSERC Disc).
- Wang, S.*, D. L. Shen*, D. Lafont, A.-S. Vercoutter-Edouart, M. Mortuaire, Y. Shi*, O. Maniti, A. Girard-Egrot, T. Lefebvre, B.M. Pinto, D.Vocadlo, S.Vidal (2014). Design of glycosyltransferase inhibitors targeting human O-GlcNAc Transferase (OGT). Comm.5: 1172-1178. (NSERC Disc).
- Adabala, P. J. P.*, E. LeGresley*, N. Bance*, M. Niikura, B.M. Pinto (2013). Exploitation of the Catalytic Site and 150 Cavity for Design of Neuraminidase Inhibitors. Org. Chem. 78: 10867−10877. doi: 10.1021/jo401854w. (NSERC Disc).
- Auzanneau, F.-I., S. Borrelli*, B.M. Pinto (2013). Synthesis and Immunological Activity of an Oligosaccharide-conjugate as a Vaccine Candidate Against Group A Streptococcus. Med. Chem. Lett. 23: 6038−6042 (NSERC Disc).
- Poulin, M.B., Y. Shi*, C. Protsko, S. A. Dalrymple, D. A. R. Sanders, B. M. Pinto, T.L. Lowary (2014). Specificity of a UDP-GalNAc Pyranose–Furanose Mutase. A Potential Drug Target for Campylobacter jejuni ChemBioChem 15: 47−56. doi: 10.1002/cbic.201300653. (NSERC Disc).
- Mohan, S.*, P.S. Kerry, N. Bance*, M. Niikura, B.M. Pinto (2014). Serendipitous Discovery of a Potent Influenza Virus A Neuraminidase Inhibitor. Chem. Int. Ed. 53: 1076—1080. (NSERC Disc).
- Shi, Y.*, B.M. Pinto (2014). Human Lactate Dehydrogenase A Inhibitors: A Molecular Dynamics Investigations. PLoS ONE 9(1): e86365. doi:10.1371/journal.pone.0086365. (NSERC Disc).
- Lira-Navarrete, E., J. Iglesias-Fernàndez, W.F. Zandberg, I. Compañón, Y. Kong, F. Corzana, B.M. Pinto, H. Clausen, J.M. Peregrina, D. Vocadlo, C. Rovira, R. Hurtaddo-Geurrero (2014). Combined structural snapshots and metadynamics reveal a substrate-guided SNi-type reaction for polypeptide GalNAc-transferase T2. Chem. Int. Ed. 53: 8206-8210. doi: 10.1002/anie. 201402781. (NSERC Disc).
- Shi, Y.*, A. Arda*, B. M. Pinto (2015). Combined Molecular Dynamics STD-NMR and Corcema Protocol Yields Structural Model for a UDP-galactopyranose Mutase-inhibitor Complex. Med. Chem Lett. 25: 1284-1287. doi: 10.1016/j. bmcl 2015.01.044. (NSERC Disc).
- Kuppala, R.*, S. Borrelli, K. Slowski*, D. A. R. Sanders, K. P. R. Kartha*, B. M. Pinto (2015). Synthesis and Biological Evaluation of Non-ionic Substrate Mimics of UDP-Galp as Candidate Inhibitors of UDP Galactopyranose Mutase. Med. Chem Lett. 25: 1995-1997. doi 10.1016/j.bmcl 2015.03.006. (NSERC Disc).
- Colombo, C., C. Aupic*, A. R. Lewis, M. Pinto (2015). In situ Determination of Fructose Isomer
Concentrations in Wine Using 13C Quantitative NMR Spectroscopy. J. Agric. Food Chem. 63: 8551-8559. DOI: 10.1021/acs.jafc.5b03641. (NSERC Disc).
- Shi, Y.*, C. Colombo, J. R. A. Kuttiyatveetil*, N. Zalatar *, K. E. van Straaten*, S. Mohan, D. A. R. Sanders, B. M. Pinto (2016). A Second, Druggable Binding Site in UDP-galactopyranose Mutase from Mycobacterium tuberculosis? ChemBioChem 17: 2264-2273. DOI: 10.1002/cbic. 201600469. (NSERC Disc).
- Sukumaran, S.K., K. K. Yee, S. Iwata, R. Kotha, R. Quezada-Calvillo, B. L. Nichols, S. Mohan , B. M. Pinto, N. Shigemura, Y. Ninomiya, R. F. Margolskee (2016). Taste cell-expressed Intestinal Brush Border Enzymes Contribute to Gustatory Responses of Disaccharides. Natl Acad. Sci. 113: 6035-6040. (CIHR).
- Mahdavi-Amiri, Y.,* S. Mohan, S. Borrelli, K. Slowski,* D. A. R. Sanders, B. M. Pinto (2016). Mechanism-based Candidate Inhibitors of Uridine Diphosphate Galactopyranose Mutase (UGM). Carbohydr. Res. 419: 1-7. (NSERC Disc).
- Colombo, C., B. M. Pinto, A. Bernardi, A. J. Bennet (2016). Synthesis and Evaluation of Influenza A Viral Neuraminidase Candidate Inhibitors Based on a Bicyclo[3.1.0]Hexane Scaffold. Org. BioMol.Chem. 14: 6539-6553. (CIHR).
- Wu, Y., F. Gao, J. Qi, Y. Bi, L. Fu, S. Mohan, Y. Chen, X. Li, B. M. Pinto, C. J. Vavricka, P. Tien, G. F. Gao (2016). Resistance to mutant group-2 influenza neuraminidases of an oseltamivir-zanamivir hybrid inhibitor. J. Virol. 90: 10693-10700. (NSERC Disc).
- Mohan, S., B. M. Pinto (2017). Exploration of the 150 Cavity and the Role of Serendipity in the Discovery of Inhibitors of Influenza Virus A Neuraminidase. Can. J. Chem., 96: 91-101 (NSERC Disc).
- Jones, C, P.W. Percival, A.J. Bennet, S. Holdcroft, N.R. Branda, B.M. Pinto, G.R. Agnes, Z.-G. Ye, D.B. Leznoff (2018). SFU Chemistry 1965–2016. Can. J. Chem. 96: V–IX.
- Mohan, S., J. Thompson, B. M. Pinto, A. J. Bennet (2018). Versatile Synthetic Route to Carbocyclic N-Acetylneuraminic Acid and its Derivatives. Tetrahedron (Special issue in honour of the 100th anniversary of Sir. Derek H.R. Barton), 74: 5213-5221. (NSERC Disc).
- Sannikov, O.*, E. Ye*, B. M. Pinto, P. Saunders, N. Merbouh (2020). Introducing Complex NMR Mixtures at the Undergraduate Level: Isomerization, Separation and Analysis of the Diels-Alder Adducts from the Reaction of Methylcyclopentadiene and Maleic Anhydride (Part II). J Lab Chem Edu 2020, 8 (3): 39-80 DOI: 10.5923/j.jlce.20200803.01
* Denotes student authors.
Invited Talks at Conferences
- Pinto, B.M. (2012). SFU Innovation Ecosystem: A Model for Canada. Roundtable on Leading Innovation: Incubators and Networks, hosted by Kevin Lynch, Vice-Chair BMO and David Mitchell, President, Public Policy Forum, Toronto, Feb. 3, 2012. Main Audience: Decision Makers
- Pinto, B.M. (2012). “SFU India Strategy: Build the Relationship.” Research Collaboration with Emerging Nations: Canada’s Experience in India and Brazil, American Association for Advancement of Science Meeting, Vancouver, Feb. 17, 2012. Main Audience: General Public
- Pinto, B.M. (2012). “What it is!” Roundtable on Communicating in a Minute: Reaching Decision Makers. American Association for Advancement of Science Meeting, Vancouver, Feb. 19, 2012. Main Audience: General Public
- Pinto, B.M. (2012). Look What you Started, Ray! NMR Methods for Probing Protein-ligand Interactions. 95th Canadian Chemistry Conference and Exhibition, Ray Lemieux Award Lecture, Calgary, May 30, 2012, Abstr. 1821. Main Audience: Researchers
- Pinto, B.M. (2012). A Tribute to the Life and Chemical Contributions of Melanie O’Neill. 95th Canadian Chemistry Conference and Exhibition, Lemieux Award Lecture, Calgary, May 27, 2012. Main Audience: Researchers
- Pinto, B.M. (2012). Modulation of Starch Digestion for Slow Glucose Release Through “Toggling” of Activities of Mucosal a-Glucosidases. 26th International Carbohydrate Symposium, Madrid, Spain, July 26, 2012. Main Audience: Researchers
- Pinto, B.M. (2012). Modulation of Starch Digestion for Slow Glucose Release Through Inhibition of Pancreatic Amylase and the Mucosal a-Glucosidases. 9th Starch Digestion Consortium Meeting, Waterloo, Ont., August 27, 2012. Main Audience: Researchers
- Pinto, B.M. (2012). Straddling Science and Politics to Promote the Future of Glycoscience. Dahlem Workshop on Glycomics. Berlin, Germany, November 18, 2012. Main Audience: Researchers
- Pinto, B.M. (2013). Probing Hyperconjugation Experimentally With the Conformational Deuterium Isotope Effect. 245th ACS National Meeting, New Orleans, Louisiana, April 7-11, 2013, Abstr. 5. Main Audience: Researchers
- Pinto, B.M. (2013). Serendipity and Nature’s Guide to Therapeutic Interventions. 96th Canadian Chemistry Conference and Exhibition, Alfred Bader Award Lecture, Quebec City, May 26-30, 2013, Abstr. 159. Main Audience: Researchers
- Pinto, B.M. (2013). Controlling Intestinal Mucosal-Glucosidase Activities with Small Molecule Inhibitors. 11th Starch Digestion Consortium Meeting, Chicago, October 13-14, 2013. Main Audience: Researchers
- Pinto, B.M. (2013). Controlled Degradation of Starch by Toggling of Intestinal Glucosidase Enzymes. ALAMY Fifth Symposium, Slovakia, October 20-24, 2013. Main Audience: Researchers
- Pinto, B.M. (2014). From an Ayurvedic Treatment for Type-2 Diabetes to the Controlled Degradation of Starch. The 27th International Carbohydrate Symposium, Bangalore, India, January 12-17, 2014. Main Audience: Researchers
- Pinto, B.M. (2014). IRMACS as the Conduit between the Research Community and Secure Computing. IRMACS Day, April 4, 2014. Main Audience: General University Public
- Pinto, B.M. (2014). Biomedical and Health Research at SFU: Alive and Well. Health Research Day, SFU, April 10, 2014. Main Audience: Academic Researchers and Health professionals
- Pinto, B.M. (2014). Control of Starch Degradation by Intestinal Glycosidases. 12th Starch Digestion Consortium Meeting, San Diego, USA. April 30 – May 1, 2014. Main Audience: Starch Experts, Academic and Industrial.
- Pinto, B.M. (2014). Building a Culture of Innovation at Universities. Indian Oil Corporation Conference, Tamilnadu, India, May 12, 2014, Main Audience: Industrial leaders
- Pinto, B.M. (2014). Ayuverdic Treatment for Diabetes and other Metabolic Disorders. Dinner speaker at Indian Oil Corporation Conference, R & D Conclave: Emerging Technologies for Sustainable Growth. TamilNadu, India, May 12, 2014. Main Audience: Industrial leaders
- Pinto, B.M. (2014). Ramblings of a Chimeric Researcher/Administrator: Montreal Medal Lecture. The Future of Chemistry Symposium, 97th CSC Conference and Exhibition, Vancouver, June 1, 2014. Main Audience: Academic and Industrial leaders
- Pinto, B.M. (2014). New Inhibitors of Influenza Virus A Neuraminidase. The Future of Chemistry Symposium, 97th CSC Conference and Exhibition, Vancouver, June 2, 2014. Main Audience: Academic and Industrial leaders
- Pinto, B.M. (2014). Building a Culture of Innovation at Universities. The Future of Chemistry Symposium, CSC Conference, Vancouver, June 2, 2014. Main Audience: Academic and Industrial leaders.
- Pinto, B.M. (2015). The Innovation Continuum. Conference Board of Canada. April, 2015. Main Audience: Academic, Business, and Industrial leaders.
- Pinto, B.M. (2015). New Inhibitors of Viral Neuraminidases. Conference on AntiViral Therapies. University of Texas, Austin, Texas, USA, June 2, 2015. Main Audience: Academic leaders.
- Pinto, B.M. (2015). New Inhibitors of Viral Neuraminidases. Symposium in Honour of David Bundle. University of Alberta, Edmonton, Alberta, Canada. July 19, 2015. Main Audience: Academic leaders.
Conference Proceedings
- Zandberg, W.F., J. Kumarasamy, T. M. Gloster, B. M. Pinto, D. J Vocadlo. Trojan Horse Inhibition of Glycosyltransferases in Cells: Controlling the Cell-surface Expression of Glycans. Gordon Conference on Carbohydrates, West Dover, VT, USA. June 16-21, 2013.
- Kerry, P., S. Mohan, R.J. Russell, N. Bance, M. Niikura, B.M. Pinto. Structural Basis for a class of nanomolar Group-1 and Group-2 Neuraminidase Inhibitors. Gordon Conference on Carbohydrates, West Dover, VT, USA. June 16-21, 2013.
- Mohan, S., A.J. Bennet, B.M. Pinto. A versatile synthetic route to carba-sialic acid and its derivatives.
27th International Carbohydrate Symposium, Bangalore, India. January 12, 2014.
- Mohan, S., P.S. Kerry, N. Bance*, M. Niikura, B.M. Pinto. New Inhibitors of Influenza Virus A
Neuraminidases. 10th National Carbohydrate Symposium, Canmore, AB. May 7, 2014.
- Auzanneau F-I., S. Borrelli, B.M. Pinto. Synthesis and Immunological Activity of an Oligosaccharide conjugate as a Vaccine Candidate Against Group A Streptococcus. 97th Canadian Chemistry Conference and Exhibition, Vancouver, B.C. May 31, June 5, 2014.
- LeGresley, E.B.*, P.J.P. Adabala, M. Niikura, N. Bance *, B.M. Pinto. Exploitation of the Catalytic Site and 150 Cavity for Design of Influenza A Neuraminidase Inhibitors With Novel Triazole Containing Compounds. 97th Canadian Chemistry Conference and Exhibition, Vancouver, B.C. May 31, June 5, 2014.
- Mohan, S., A.J. Bennet, B.M. Pinto. A Versatile Synthesis of Carba-sialic Acid and its Derivatives. 97th Canadian Chemistry Conference and Exhibition, Vancouver, B.C. May 31, June 5, 2014.
- Shi, Y.*, V. Winton*, L.L. Kiessling, B.M. Pinto. Binding Models for Non-substrate-like Inhibitors of UDP-galactopyranose Mutase. 97th Canadian Chemistry Conference and Exhibition, Vancouver, B.C. May 31, June 5, 2014.
- Colombo, C., A. Bernardi, B.M. Pinto. Design and Synthesis of Potential Group-1 and Group-2 Neuraminidase Inhibitors. 97th Canadian Chemistry Conference and Exhibition, Vancouver, B.C. May 31, June 5, 2014.
- Challa, V.R.*, B.R. Hossany*, B.M. Pinto. Synthesis of a Chimeric Glycopeptide Corresponding to the Shigella flexneri Y O-polysaccharide and its Peptide Mimic MDWNMHAA. 97th Canadian Chemistry Conference and Exhibition, Vancouver, B.C. May 31, June 5, 2014.
- Reddy, K.R., B.M. Pinto. Inhibiting the Individual Enzyme Activities of Starch-DigestingMaltase-Glucoamylase and Sucrase-Isomaltase by α- and β-Maltose ExtendedPonkoranol Analogues. 97th Canadian Chemistry Conference and Exhibition, Vancouver, B.C. May 31, June 5, 2014.
- Mahdavi-Amiri, Y.*, B.M. Pinto. Potential Uridine Diphosphate Galactopyranose Mutase (UGM) Inhibitors as Therapeutic agents for the Treatment of Mycobacterium tuberculosis Infections. 97th Canadian Chemistry Conference and Exhibition, Vancouver, B.C. May 31, June 5, 2014.
- Mohan, S., B.M. Pinto. New Inhibitors of Influenza Virus A Neuraminidase. The Future of Chemistry Symposium, 97th Canadian Chemistry Conference and Exhibition, Vancouver, B.C. May 31, June 5, 2014.
- Bennet, A.J., N. Sannikova, S. Mohan, J. Drapper, B.M. Pinto, R. Britton. Synthesis of Carbocyclic Sugar Analogues. 97th Canadian Chemistry Conference and Exhibition, Vancouver, B.C. June 5, 2014.
- Colombo, C., C. Aupic, S. Mohan, A. Lewis, B. M. Pinto. Measuring sugar content in beverages by
13C- NMR spectroscopy. 8th Annual VIVA NMR Symposium. St. John’s College, UBC, Vancouver. August 8, 2014.
- Aupic, C., C. Colombo, A. Lewis, B. M. Pinto. Quantitative determination of fructose structural
isomers in wine by 13C NMR spectroscopy. 8th Annual VIVA NMR Symposium. St. John’s College, UBC, Vancouver. August 8, 2014. (Winner of poster competition)
Special Lectureships
- Pinto, B.M. (2015). Ramblings of a Chimeric Researcher/Administrator (Audience: University academics and General Public) and Serendipity and Nature’s Guide to Therapeutic Interventions (Audience: University academics). Peter Gallagher Memorial Glycomics Lecturer. Griffith University, Gold Coast, Australia. October 12, 2015.
- Pinto, B.M. (2015). Serendipity and Nature’s Guide to Therapeutic Interventions (Audience: University academics). K.N. Jones Lecturer. Queen’s University, Kingston, Ontario. October 23, 2015.
- Pinto, B.M. (2015). The Innovation Continuum. How can we do Better? (Audience: University academics, business and industrial workers). Queen’s University, Kingston, Ontario. October 22, 2015.
PATENTS (2009 – Present)
Provisional Patents
9. Jayakanthan, K., B.M. Pinto (2009). Novel Seven-Carbon Chain-Extended Homologues of the Glycosidase Inhibitor Salacinol and Method for Synthesizing Same. US 61/146531, filed, January 22.
- Jayakanthan, K., S. Mohan, B.M. Pinto (2009). Novel Seven-Carbon Chain-Extended Homologues of the Glycosidase Inhibitor Salacinol and Method for Synthesizing Same. 61/150672, filed, February 6.
- Pinto, B.M., K. Jayakanthan, S. Mohan, R. Eskandari, R. Nasi (2009). Salacinol Homologues, Derivatives Thereof, and Methods of Synthesizing Same. US 61/265695, filed December 1, 2009.
Patents Issued/Granted
- Pinto, B.M., K. Jayakanthan, S. Mohan, R. Nasi (2009). Methods for Synthesizing Kotalanol and Stereoisomers and Analogues Thereof, and Novel Compounds Produced Thereby, PCT /CA2009/000397, filed, March 25, 2009. Australia Granted Patent 31043840[IS1], August 12, 2013. (CIHR)
Patents Pending
- Pinto, B.M., K. Jayakanthan, S. Mohan, R. Nasi (2009). Methods for Synthesizing Kotalanol and Stereoisomers and Analogues Thereof, and Novel Compounds Produced Thereby, PCT /CA2009/000397, filed, March 25, 2009. (CIHR). USA, EUROPE, CANADA, AND INDIA.
- Pinto, B.M., S. Mohan (2009). Compounds and Methods for Treatment of Influenza. PCT/CA 2009/001907, filed December 30, 2009. (NSERC Disc). USA.
- Pinto, B.M., S. Mohan, R. Nasi, K. Jayakanthan, R. Eskandari (2010). Salacinol and Ponkoranol Homologues, Derivatives Thereof, and Methods of Synthesizing Same. PCT/CA2010/001921, filed December 1, 2010. (CIHR). USA, EUROPE, INDIA, AND CANADA.
ENTIRE PATENT PORTFOLIO LICENSED BY FUJI-SANYO, JAPAN, 2018.