Judy Anderson

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Name: Judy Anderson

Position Title: Professor Emeritus

Office Phone Number: (204) 474-9730

Research and Teaching Interests

Cell and Development, muscle regeneration, muscle satellite/stem cell biology, comparative development and regulation in skeletal muscle, neuromuscular junctions, regulation of activation by nitric oxide, HGF- cmetR signaling in satellite cell activation, fiber cytoskeleton,age-related atrophy.

Research projects in the lab include experiments that examine:

processes of satellite cell activation in normal, old and regenerating skeletal muscles
regulation of satellite cell activation and quiescence in different species (fish, mouse, human)
cytoskeletal proteins and muscle fiber stability in development and disease
human muscle disease pathophysiology and response to treatment
muscle-specific responses in relation to outcomes of disease and treatment
in vivo studies of muscle responses to Nitric Oxide-donor drugs and exercise in dystrophy and aging
in vivo studies of re-innervation during muscle regeneration

Topics such as the mechanisms of cell injury in normal and dystrophic muscle, compensatory muscle regeneration and hypertrophy, and the effects of various therapies or voluntary exercise on muscle repair, satellite cell activation, muscle growth, bone density and age-related atrophy are examined using a large variety of cellular, molecular and whole-animal in vivo assays of function. In human studies, the measures are clinical assessment techniques and in vitro assays of biopsy-muscle status, cell proliferation, and gene expression.

Students receive training with a ‘systems’ biology approach through courses, bench work, lab discussions and publications spanning a broad range of muscle-biology questions using studies at the level of single cells, tissues, animals and humans. Education research has the goal to help improve health care through interprofessional learning.

Studies of satellite cell activation via nitric oxide have opened an exciting area of research on muscle regeneration, growth and the muscle-fiber cytoskeleton that integrates mechanical and biochemical signal transduction with cell and molecular biology of muscle tissue in growth, development, disease, aging and evolution.

Gigliotti D, Leiter JRS, Macek B, Davidson MJ, MacDonald PB, Anderson JE (2015). Atrophy, inducible satellite cell activation and possible denervation of supraspinatus muscle in injured human rotator-cuff muscle. Amer J Physiol Cell Physiol 309, 383-391.full text of article
Sakaguchi S, Shono J-i, Suzuki T, Do M-K Q, Mizunoya W, Nakamura M, Sato Y, Furuse M, Yamada K, Ikeuchi Y, Anderson JE, Tatsumi R. (2014). Anti-inflammatory macrophages may promote myoblast migration and neural chemorepellent Semaphorin 3A expression at the early-differentiation phase of muscle regeneration. International Journal of Biochemistry & Cell Biology 54, 272-285.
Sharma P, Basu S, Mitchell RW, Stelmack GL, Anderson JE, Halayko AJ. (2014). Role of dystrophin in airway smooth muscle phenotype, contraction and lung function. PLoS ONE 9, e102737.
Snow WM, Anderson JE, Fry M. (2014). Regional and genotypic differences in intrinsic electrophysiological properties of cerebellar Purkinje neurons from wild-type and dystrophin-deficient mdx mice. Neurobiology of Learning & Memory 107, 19-31.
Thomas MM, Wang DC, D’Souza DM, Krause MP, Layne AS, Criswell DS, O’Neill HM, Connor MK, Anderson JE, Kemp BE, Steinberg GR, Hawke TJ. (2014). Muscle-Specific AMPK β1β2-null mice display a myopathy resultant from impairments in blood flow.FASEB Journal 28 (2098-2107).
Zhang H, Anderson JE. (2014). Satellite cell activation and populations on single muscle-fiber cultures from adult zebrafish (Danio rerio). Journal of Experimental Biology 217 (11), 1910-1917.
Snow WM, Stoesz BM, Anderson JE. (2014, May). The cerebellum in emotional processing: evidence from human and non-human animals. AIMS Neuroscience.
Janke A, Upadhaya R, Snow WM, Anderson JE. (2013). A new look at cytoskeletal NOS-1 and β-dystroglycan changes in developing muscle and brain in control and mdx dystrophic mice. Dev Dynamics, in press July 2013.
Lee ASJ, Anderson JE, Joya JE, Head SI, Pather N, Kee AJ, Gunning PW, Hardeman EC. (2013). Regeneration efficiency in skeleatl muscle depends on the type of injury, not age. Bioarchitecture 3, 25-37.
Snow WM, Anderson JE, Jakobson LS. (2013). Neuropsychological and neurobehavioral functioning in Duchenne muscular dystrophy: a review. Neurosci Biobeh Rev 37, 743-752.
Snow WM, Fry WM, Anderson JE. (2013). Increased density of dystrophin protein in the lateral vs. vermal mouse cerebellum. Cell Molec Neurobiol 33, 513-520.
Suzuki T, Do M-KQ, Sato Y, Ojima K, Hara M, Mizunoya W, Nakamura M, Furuse M, Ikeuchi Y, Anderson JE, Tatsumi R. (2013). Comparative analysis of semaphorin3A in soleus and EDL muscle satellite cells in vitro toward understanding its role in modulating myogenin expression. Int J Biochem Cell Biol 4, 476-482.
Takacs J, Leiter JRS, Anderson JE, Peeler JD. (2013). Lower body positive pressure: an emerging technology in the battle against knee osteoarthritis?. Clinical Interventions in Aging 8, 983-991.
Do MKQ, Suzuki, Gerelt B, Sato Y, Mizunoya W, Nakamura M, Ikeuchi Y, Anderson JE, Tatsumi R. (2012). Time-coordinated prevalence of extracellular HGF, FGF2 and TGF-β3 in crush-injured skeletal muscle. Animal Science Journal 83, 712-717.
Leiter JRS, Upadhaya R, Anderson JE. (2012). Age-related atrophy and cytoskeletal remodelling in mice reversed by treatment with NO-donor in combination with voluntary exercise. . Amer J Physiol: Cell Physiol 302, C1306-C1315.
Anderson JE, Ateah C, Metge C, Wener P, Snow W, Fricke M, Davis P, MacDonald L, Ludwig S. (2011). Differences in pre-licensure interprofessional learning: classroom versus practice settings. Journal of Research on Interprofessional Education 2. www.jripe.org/index.php/journal/article/view/54
Do MQ, Sato Y, Shimizu N, Suzuki T, Shono J, Mizunoya W, Nakamura W, Tatsumi R, Ikeuchi Y, Anderson JE, Tatsumi R. (2011). Growth factor regulation of neural chemorepellent Sema3A expression in satellite cell cultures. Am J Physiol: Cell Physiol 301, C1270-C1279.
Leiter JRS, Peeler J and Anderson JE. (2011). Exercise-induced muscle growth is muscle-specific and age-dependent. Muscle & Nerve 2011, 828–838.
Mizunoya M, Upadhaya R, Burczynski FJ, Wang G, Anderson JE. (2011). Nitric-oxide donors improve prednisone effects on muscular dystrophy in the mdx mouse diaphragm. Amer J Physiol Cell Physiol 300, C1065-1077.
Upadhaya R, Mizunoya W, Anderson JE. (2011). Multiple-protein analysis in Western blotting using hydrogen peroxide. Analytical Biochemistry 419, 342–344.
Anderson JE, Wozniak AC, Mizunoya W. (2010). Single muscle-fiber isolation and culture for cellular, molecular, pharmacological, and evolutionary studies, pp. 85–102. Springer Protocols by Humana Press .
Tatsumi R, Sankoda Y, Anderson J, Sato Y, Mizunoya W, Shimizu N, Suzuki T, Yamada M, Rhoads RP, Ikeuchi Y, Allen RE. (2009). Possible implication of satellite cells in regenerative motoneuritogenesis: HGF up-regulates neural chemorepellent Sema3A during myogenic differentiation. . Am J Physiol Cell Physiol 297, 238–252.
Wang GQ, Burczynski FJ, Hasinoff B, Zhang KD, Lu Q, Anderson JE. (2009). Development of a nitric oxide-releasing analog of the muscle relaxant guaifenesin for skeletal muscle satellite cell myogenesis. . Molecular Pharmaceutics 6, 895–904.
Wozniak A, Anderson JE. (2009). The dynamics of the nitric oxide release-transient from stretched muscle cells. International J Biochem Cell Biol 41, 625–631.
Peeler J, Anderson JE. (2007). Effectiveness of static quadriceps stretching in individuals with patellofemoral joint pain. Clinical Journal of Sport Medicine 17, 234–241.