Positions Available

Research Associate (RA) in Chemical Synthetic Biology – Position Number 30320

Synthetic biology of modular antibiotic materials and expressed protein-based nanodevices using an expanded genetic code.

Newly established Tier 1 Canada Research Chair (CRC) in Chemical Synthetic Biology in the Department of Chemistry (see: www.chemsynbio.com) has a mission of founding the Canadian Center for Chemical Synthetic Biology (CCCSB) to establish and foster world-class research excellence in Synthetic Biology in Canada. The established CRC aligns with the University’s strategic research plan that identifies High Performance Complex Biological Scaffolds, Structures and Processes as a targeted research area (http://umanitoba.ca/research/media/Strategic_Research_Plan.pdf ).

These new protein-based modules will be used in microbial cell factories, composite multi-enzyme cascades, energy storage, auto parts, water filters, bioelectronic computers and sensors, coatings, electromagnetic shielding, electronic circuit scaffolds including thin-film electronics, renewable energy sources for fine chemistry and pharmaceutical production or soil remediation, mining and fertilization and much more.

In this context, we are searching for a highly motivated candidate with an outstanding interdisciplinary expertise (acquired during PhD and Postdoc work) and motivation to work at the interface between cell biology, molecular biology of proteins, ribosomally synthetized peptides (preferably for biomedical applications) and the expanded genetic code. Besides the proof of strong publication record in these research areas, the recommendations of prominent researches in the field of structural biology, expanded genetic code, and biochemistry (work in molecular biology of proteins in particular) are highly desirable. The position is limited to three years (beginning at October 1st, 2021), but could be extended by successful grant applications. Salary and will be commensurate with experience and qualifications.

Responsibilities :

Description of tasks: Under the direction of the CRC the individual will conduct independent research to combine directional evolution, biosystem engineering, and extension of the genetic code to create new biomaterials based on complex biological scaffolds and architectures for various practical applications. First and foremost, the task is the development of recombinant proteins for bone surgery and wound healing followed by the development of biological nanodevices for materials science and various technologies. The work will be focused on coupling genetic-code expansion with artificial metabolism in the context of bio-contained bacterial cell factories. With this technology, the production of mussel bio-adhesives which are protein-based natural polymeric materials with the potential to revolutionize small-bone surgery and wound healing will be achieved.

Task 2: Planned work include the design of nanodevices that should allow the application of bioorthogonal chemistries to genetically encoded scaffolds (based on bacterial flagella, archaeal S-layers, viral particles and whole cells) by using inexpensive starting materials. This research is expected to be essential to provide innovative scientific and technological solutions to the problems that cannot be solved under current conventional methods (e.g., carbon-based nanotubes). Here, the expertise in recombinant DNA technology and bioorthogonal chemistries is crucial.

Qualifications:

Requirements: Successfully completed PhD in biochemistry, biocatalysis or a related field with excellent scientific performance in the above-mentioned research areas. Excellent knowledge and know-how in the most advanced methods of molecular cloning, library design and screening with industrially highly relevant enzymes (including their immobilization) and protein-based complexes (device assembly, such as multi-enzyme cascades or nanocarriers for efficient anti-cancer drug delivery) is desirable. In addition, analytical capabilities in screening, extraction and purification as well as structure elucidation of bio-based materials with medicinal properties are of particular importance. In addition, the experience in the metagenomic search for enzymes and bioactive compounds in exotic habitats (e.g. salt lakes) and archaeal species and their bioinformatics are very beneficial. Finally, interdisciplinary work and communication with various specialists in the fields of biocatalysis, enzyme engineering, biomaterials research, molecular biology and biomedicine, including the interest in academic exchange with students attending postgraduate courses, are important prerequisites.

Additional Information:

To apply, please send a CV, a publication list, a description of relevant experience (ideally all merged in a single PDF) and have three reference letters sent by email to chemform@umanitoba.ca.

Review of applications will begin April 19, 2021 and will continue until the position is filled.

The University of Manitoba is strongly committed to equity and diversity within its community and especially welcomes applications from women, racialized persons, Indigenous peoples, persons with disabilities, persons of all sexual and gender identities, and others who may contribute to the further diversification of ideas. All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

If you require accommodation supports during the recruitment process, please contact UM.Accommodation@umanitoba.ca or 204-474-7195. Please note this contact information is for accommodation reasons only.

Application materials, including letters of reference, will be handled in accordance with the protection of privacy provision of the Freedom of Information and Protection of Privacy (Manitoba). Please note that curriculum vitae may be provided to participating members of the search process.

Indigenous Scholar at Faculty of Science (Assistant or Associate or Full Professor) – Position # 29312 and 29313

The Faculty of Science at the University of Manitoba invites applications from Indigenous (e.g., First Nations (status or non-status), Métis or Inuit) Scholars in any field of science for two full-time tenured or tenure-track positions at the rank of Assistant or Associate or Full Professor, commencing July 1, 2021, or on a date mutually agreed upon. Rank and salary will be dependent on qualifications and experience. Candidates who are either of Canadian Indigenous background or are Indigenous in their respective countries/territories and whose work complements and supports the education, research, and Indigenous initiatives within the Faculty of Science and at the University of Manitoba are invited to apply.

We seek an emerging or established scholar with a commitment to excellence in teaching, researchand community outreach. The successful candidate will have a Ph.D. in any field of science and have demonstrated experience in, and commitment to, leadership and mentorship related to Indigenous student achievement and engagement. Relevant research, industry, or community experience or other distinguishing attributes are considered an asset. Duties will include undergraduate teaching, graduate teaching, and student research supervision; research, including the establishment of an externally funded research program; and service and community activities.The relative division of activities for the successful candidate between teaching, research, and service/community activities are flexible. Salary will be commensurate with experience and qualifications. Appointment can be in any department in the Faculty of Science or joint across multiple departments.

The Faculty of Science comprises the departments of Biological Sciences, Chemistry, Computer Science, Mathematics, Physics and Astronomy, Microbiology, and Statistics and features many additional interdisciplinary programs and activities, at both the undergraduate and graduate levelsthat cross departmental boundaries. The Faculty of Science 50th Anniversary Challenges for the coming decades commit us to important work in the following challenge areas: Explore Life on the Smallest Scales, Harness Microbial and Genetic Worlds, Transform Tomorrow’s Devices, Make Computers our Sixth Sense, Revolutionize Science and Math Literacy for the 21st Century, Expand our Contribution to the Innovation Ecosystem, Leverage the Origins of the Universe, Reconnect Nature’s Networks, and Cultivate Remote and Rural Communities. The Faculty of Science has a deep commitment to educational excellence and a strong and active community of science educators, including the Pedagogy and Learning Science working group, and features the newly created Manitoba Institute for Science Teaching.The Faculty of Science has launched a major new initiative, the Wawatay Program, in order to develop closer ties to Indigenous communities, dramatically grow the number of Indigenous science graduates, infuse Indigenous science approaches and perspectives into science education and strengthen mutual research. In summer of 2021, we will be hosting a major new international conference, “The 2021 North America Indigenous Science Conference”.

The University is located in Winnipeg, the largest city in the province of Manitoba. The city has a rich cultural environment and the region provides exciting opportunities for outdoor exploration and recreation in all seasons. Learn more about Winnipeg at www.winnipeg.ca.

Manitoba’s Indigenous population is young and rapidly growing. Statistics Canada census data suggest that Indigenous peoples will comprise nearly 19 per cent of Manitoba’s population by 2026. The University of Manitoba’s role in reconciliation, its connections with Indigenous students, partners and communities, and its commitment to Indigenous achievement are central to the kind of future the University seeks to create.

The University of Manitoba campuses are located on original lands of Anishinaabeg, Cree, Oji-Cree, Dakota, and Dene peoples, and on the homeland of the Métis Nation. Creating Pathways to Indigenous Achievement is a key priority for the University, as identified in its 2015-2020 strategic plan, Taking Our Place. Home to a vibrant Indigenous community, including 2,400 First Nations, Métis and Inuit students, the U of M has one of the largest Indigenous student populations in the country. Honoured to be chosen as host of the National Centre for Truth and Reconciliation, the U of M is dedicated to advancing Indigenous research and scholarship, and to becoming a centre of excellence for this work.

The University of Manitoba is strongly committed to equity and diversity within its community and especially welcomes applications from women, members of racialized communities, Indigenous persons, persons with disabilities, persons of all sexual orientations and genders, and others who may contribute to the further diversification of ideas. All qualified candidates are encouraged to apply; however, Indigenous Canadian citizens and permanent residents will be given priority. Applicants must, at application, declare that he/she/they self-identifies as Indigenous (First Nations, Metis or Inuit) Canadian, or as Indigenous in their respective countries/territories.

If you require accommodation supports during the recruitment process, please contact UM.Accommodation@umanitoba.ca or 204-474-7195. Please note this contact information is for accommodation reasons only.

Applications, including a curriculum vitae, a two-page description of teaching philosophy, a two-page summary of research interests accessible to an interdisciplinary audience, a three-page research plan, a one-page plan for leadership and mentorship in the context of Indigenous student achievement in the department and Faculty of Science, the name and contact information (phone and e-mail) of three referees, and Indigenous self-declaration verification should be sent by email in a single pdf file to Indigenous_Scholars.Science@umanitoba.ca.

Priority will be given to candidates who apply before November 30, 2020, but the search will remain open until the position is filled. Application materials, including letters of reference, will be handled in accordance with the Freedom of Information and Protection of Privacy Act. Please note that curricula vitae may be provided to participating members of the search process.